At GreeneMD, we don’t just specialize in creating natural results with injectable treatments — we are also the trusted destination for patients seeking correction of disappointing treatments from other providers. People travel to see us due to our expertise in dissolving fillers and addressing complications, knowing they will receive safe, personalized care. Hyaluronidase is an enzyme that initiates the breakdown of hyaluronic acid filler. It is safe and effective, and can facilitate removal of unwanted or overdone facial fillers. Whether you’re looking to refine a previous treatment or start fresh, Dr. Greene and Holly Shipley, PA-C, will help you achieve the natural, balanced results you desire. We understand that achieving your ideal look is a journey. 

What Is Hyaluronidase (Hylenex)?

Hyaluronidase (marketed as Hylenex) is an enzyme that breaks down hyaluronic acid (HA)—the main component of most modern dermal fillers. When injected, Hylenex rapidly initiates the breakdown of HA, allowing the body to naturally absorb and eliminate the unwanted filler. This makes hyaluronidase the treatment of choice for:

  • Dissolving overdone or misplaced hyaluronic acid fillers
  • Correcting asymmetry or lumps
  • Addressing complications such as vascular occlusion or allergic reactions

Note: Hyaluronidase is only effective on HA-based fillers. It does not dissolve fillers made from substances like calcium hydroxylapatite (Radiesse), poly-L-lactic acid (Sculptra), or silicone

Why Choose GreeneMD for Filler Dissolving?

  • Expertise in Complication Management: Dr. Greene and Holly Shipley, PA-C, are recognized for their skill in safely dissolving fillers and correcting complications.
  • Personalized, Safe Care: Every treatment is tailored to your unique anatomy and goals, ensuring a natural, balanced outcome.
  • Advanced Techniques: We use precise injection and massage methods to maximize the effectiveness of hyaluronidase, especially for dense or deeply placed fillers

How Does Filler Dissolving with Hylenex Work?

The Process

  1. Consultation: We assess your filler type, placement, and goals.
  2. Customized Treatment: Hylenex is injected directly into the areas of unwanted filler. For best results, especially with tightly bound (monophasic) fillers, the area is gently massaged immediately after injection to increase contact between the enzyme and the filler.
  3. Multiple Sessions May Be Needed:
    • Filler Type & Density: Highly cross-linked or monophasic fillers are more resistant and may require higher doses or multiple sessions.
    • Amount of Filler: Larger volumes need more enzyme and often more than one treatment for even, thorough results.
    • Location: Deeply placed fillers, such as in the tear trough (under-eye), can be harder to access and dissolve completely.
    • Patient Response: Individual differences mean some patients see immediate results, while others need further sessions.
    • Safety: Gradual dissolution prevents unevenness and supports optimal skin adaptation.

What to Expect

  • Quick Results: Most patients notice improvement within 24–48 hours after treatment.
  • Minimal Downtime: You can usually return to normal activities immediately, though some swelling or redness is possible.
  • Follow-Up: A check-up is recommended 24–72 hours after injection to assess results and determine if further treatment is needed.

When Is Hyaluronidase Used?

  • Correction of Overfilled or Uneven Results: Restore a more natural appearance if you are dissatisfied with previous filler treatments.
  • Emergency Treatment: In rare cases, HA fillers can block blood vessels (vascular occlusion)—hyaluronidase can rapidly dissolve the filler and restore blood flow, preventing tissue damage.
  • Allergic Reactions: Very rarely, allergic responses to HA fillers can be treated with hyaluronidase.

Safety and Side Effects

Hyaluronidase is generally safe when administered by experienced professionals. Side effects are typically minor and may include temporary swelling, redness, or bruising at the injection site. Allergic reactions are rare but possible, especially in individuals with bee or wasp sting allergies. Overcorrection (removal of too much filler or natural HA) is avoided by starting with a minimal dose and increasing only if necessary.

Why Experience Matters

  • 3-D Anatomical Knowledge: An in-depth understanding of facial anatomy allows precise targeting of filler, minimizing risk to surrounding tissues.
  • Customized Approach: Every patient’s filler placement and goals are unique, requiring a tailored treatment plan.
  • Risk Avoidance: Incorrect application can lead to complications such as over-dissolving or inadequate correction. Trusting an expert ensures the safest, most effective outcome

Frequently Asked Questions

How does hyaluronidase work?

Hyaluronidase breaks down hyaluronic acid, the main component of most fillers, into smaller molecules that your body naturally absorbs and eliminates.

What formulation of hyaluronidase do you use?

There are a number of commercially available hyaluronidase products. Many are animal-derived (such as Vitrase) and therefore carry a risk of allergic reactions. With these animal-derived products, prior allergy testing is recommended. For this reason, we use a recombinant (non animal-derived) form called Hylenex. We feel that this is a safer alternative.

How long does it take to see results?

Results are often noticeable within 24-48 hours, but the full effects may take up to a week as your body processes the dissolved filler.

Is hyaluronidase treatment painful?

In our vast experience, treatments with Hylenex usually produce the same (or often, less) level of discomfort as filler treatments. It is unclear why so many people on social media report significant pain during hyaluronidase treatments, but this is likely due to technique.

Are there any side effects of a hyaluronidase treatment?

Common side effects include mild swelling, redness, or bruising at the injection site, which typically resolve within a few days. While some formulations carry the risk of allergy and require skin testing, we choose to use Hylenex, which is a safer alternative that does not require prior skin testing.

Can I get new filler after Hylenex treatment?

While the enzyme process occurs quickly, it is generally recommended to wait at least two weeks after the Hylenex treatment to allow any residual swelling to subside and ensure proper evaluation. In some cases, we can dissolve and add filler in the same day if the area being dissolved is small and/or localized.

How do I know if I need Hylenex?

If you are unhappy with the results of a previous filler treatment, schedule a consultation at GreeneMD. Our expert team will assess your concerns and recommend the best course of action.

Book Your Filler Dissolving Consultation

If you’re ready to correct unsatisfactory filler results or want to start fresh, contact GreeneMD today to schedule your expert hyaluronidase (Hylenex) consultation. Our team is dedicated to helping you achieve safe, beautiful, and balanced results.

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